May 31, 2021 — Very happy to see this collaborative paper with the Jie Xiao lab at Johns Hopkins out in Nature Methods. We helped develop a method for reducing blinking and over-counting artefacts in SMLM. Congrats to all involved and in particular Shreyasi Thakur from the Lakadamyali lab for spearheading the validation studies: https://www.nature.com/articles/s41592-021-01154-y
Our collaborative paper with Holzbaur and Ostap labs out in MBoC
April 19, 2021 — Our paper on Cega: a new tool for segmenting and identifying moving single molecules in noisy experiments is out in MBoC and has been selected as a Highlight by MBoC. This has been a super fun collaboration with the labs of Mike Ostap and Erika Holzbaur at Penn. Congratulations Erin and Peter: https://www.molbiolcell.org/doi/full/10.1091/mbc.E20-11-0744
CMT Study Section
April 15, 2021 — Melike becomes a standing member of the Cellular and Molecular technologies (CMT) Study Section at the NIH. She is excited to do her part to serve this community.
Our paper on Tau aggregates just out in PNAS
March 29, 2021 — Our paper on super-resolution imaging of tau aggregation is out in PNAS! Congratulations to Melina, Elena, Arian and Adriana! https://www.pnas.org/content/118/19/e2021461118.short?rss=1
Highlight in PNAS: https://www.pnas.org/content/118/19/eiti1921118
Highlight by Penn Medicine: https://www.pennmedicine.org/news/news-releases/2021/may/new-method-identifies-tau-aggregates-occurring-in-healthy-body-structures
Congratulations Melina for rocking it again!
March 17, 2021 — Congratulations to Melina for receiving a SAS Dissertation Completion fellowship!
Congratulations Melina!
February 24, 2021 — Graduate student Melina Gyparaki receives an SRAA Poster Award at the Biophysical Society Meeting
Collaborative work with Blobel lab out in Cell Reports
February 2, 2021 — Our collaborative paper with the Blobel lab on CTCF dynamics is out in Cell Reports: https://www.sciencedirect.com/science/article/pii/S2211124721000966
Congratulations Angel
January 5, 2021 — Congratulations to graduate student Angel on his wedding!
Preprint Alert
January 1, 2021 — “Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells” by Heo et al is out in bioRxiv: https://www.biorxiv.org/content/10.1101/2021.04.27.441596v1.abstract
Latest paper in Cell Reports!
January 1, 2021 — Former graduate student Pablo-Gomez Garcia publishes his first author paper in Cell Reports studying the dynamics of single nucleosomes: https://www.sciencedirect.com/science/article/pii/S221112472031603X
UO1 Grant from 4DN
December 1, 2020 — Lakadamyali lab receives a UO1 grant from the 4DN consortium to study nuclear organization in disease in collaboration with Cremins, Joyce, Jain and Vahedi labs at Penn
Collaboration with Zaret lab out in Molecular Cell!
August 20, 2020 — Our collaborative paper with the Zaret lab on transcription factor mobility in the nucleus is out in Molecular Cell: https://www.sciencedirect.com/science/article/pii/S1097276520303579
Melike's Promotion
July 1, 2020 — Melike has been promoted to Associate Professor at Penn! She is grateful to all her lab members past and present for their contributions as well as all her scientific mentors, collaborators at Penn and beyond!
Collaborative work with Mauck Lab in Science Advances
June 1, 2020 — We are thrilled to have contributed to this paper out by our close collaborators Su Chin Heo and Rob Mauck in Science Advances: https://advances.sciencemag.org/content/6/25/eaax5083.abstract
Welcome Qing!
April 1, 2020 — We welcome Qing Tang, a new postdoc in the lab who will be studying microtubule PTMs and intracellular transport
Perspective on Genome Organization in Nature Methods
March 2, 2020 — A perspective article on genome organization from the lab is out in Nature Method: https://www.nature.com/articles/s41592-020-0758-3
Preprint alert
January 1, 2020 ORP1L regulates dynein clustering on endolysosmal membranes in response to cholesterol levels by Thakur et al is out in bioRxiv: https://www.biorxiv.org/content/10.1101/2020.08.28.273037v5.abstract
NIH-NIGMS-RM1
The Lakadamyali lab is excited to receive a collaborative RM1 grant from NIH-NIGMS, together with the Ostap, Holzbaur, & Dominguez labs at UPenn, and the Vavylonis lab at Lehigh University! We will study the mechanisms of mitochondrial transport from atomistic to cell biological level.
Read MoreInstitute on Aging Pilot Grant
The Lakadamyali lab is excited to receive a pilot grant from the IOA at UPenn to study tau aggregation using super-resolution microscopy!
Read MoreCollaboration with Epstein Lab in eLife
Our collaborative work with the Epstein lab on the role of H3K9me2 on heterochromatin positioning is published in eLife. Congratulations to Andrey and all the co-authors.